E2f1 Overexpression Reduces Aging-Associated DNA Damage in Cultured Cerebral Endothelial Cells and Improves Cognitive Performance in Aged Mice
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As we age, cerebral endothelial cells (CECs) are less efficient in maintaining genome integrity and accumulate DNA damage. DNA damage in the brain endothelium can lead to the impairment of the blood-brain barrier (BBB), which is a major factor in brain dysfunc... ...
