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Evaluation of toxicological profile of omeprazole degradation impurities in an intravenous drug product: omeprazole-sulfone and omeprazole-N-oxide

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Omeprazole (OMZ) is a widely used proton pump inhibitor for the treatment of acid-related gastrointestinal disorders. Degradation during the manufacture and storage of the drug substance or drug product may lead to the formation of impurities. When these impur... ...