Synthesis of Thiophenes from Pyridines Using Elemental Sulfur
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We describe a skeletal editing of pyridines to afford thiophenes through a formal [4 + 1] reaction using elemental sulfur. 2-Arylpyridines are converted to ring-opened aza-triene Zincke ketone structures, followed by simple treatment with sulfur to give 2-aroy... ...
