Deciphering the bidirectional catalytic mechanism of HGPRT from Mycobacterium tuberculosis: Functional mapping of key active-site residues
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As the number of tuberculosis cases worldwide has increased, the enzyme hypoxanthine-guanine phosphoribosyltransferase from Mycobacterium tuberculosis (MtHGPRT) has emerged as a promising target for drug development because of its role in purine salvage and nu... ...
