Engineering Streptomyces coelicolor for heterologous expression of the thiopeptide GE2270A - a cautionary tale
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The thiopeptide GE2270A is a clinically relevant, ribosomally synthesised and post-translationally modified peptide (RiPP) naturally produced by Planobispora rosea. Due to the genetically intractable nature of P. rosea, heterologous expression is considered a ... ...
