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Involvement of Cranial Nerve Ganglion as an Independent Risk Factor for Malignant Transformation of Head and Neck Plexiform Neurofibromas in Neurofibromatosis Type 1

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Background: Individuals with neurofibromatosis type 1 (NF1) are confronted with a 10% lifetime susceptibility to malignant peripheral nerve sheath tumors (MPNST). The majority of NF1-associated MPNST arise from pre-existing plexi... ...