Beyond proofreading: POLD1 mutations as dynamic orchestrators of genomic instability and immune evasion in cancer
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DNA polymerase delta (Pol δ) is a cornerstone of genomic stability, orchestrating DNA replication and repair through its catalytic subunit, POLD1. This subunit's 3'-5' exonuclease domain proofreads replication errors, ensuring fidelity. However, POLD1 muta... ...
