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Secretagogin Downregulation Impairs Nerve Cell Migration in Hirschsprung Disease via Inhibition of the LEF-1/NCAM1 Axis

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Hirschsprung disease (HSCR) is a common peripheral neurodevelopmental disorder, and impaired enteric neural crest cell (ENCC) migration is one of the key factors. Secretagogin (SCGN) has been demonstrated to play a critical role in the rostral migratory stream... ...