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Identification and Characterization of Novel Inhibitors of Human Poly(ADP-Ribose) Polymerase-1

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Poly(ADP-ribose) polymerases (PARP) are a family of enzymes that were proven to play an essential role in the initiation and activation of DNA repair processes in the case of DNA single-strand breaks. The inhibition of PARP enzymes might be a promising option ... ...