A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients
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Organelles such as lysosomes and synaptic vesicles are acidified by V-ATPases, which consist of a cytosolically oriented V1 complex that hydrolyzes ATP and a membrane-embedded VO complex that pumps protons. In yeast, V1-VO association is facilitated by the RAV... ...
