Design of novel imidazo[1,2- a]pyrimidines as Plasmodium falciparum dihydroorotate dehydrogenase (Pf DHODH) inhibitors using fragment-based and other integrated in silico approaches
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Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) is a well-established target for developing novel antimalarial agents. Novel imidazo[1,2-a]pyrimidines were designed as PfDHODH inhibitors using a fragment-based drug design (FADD) approach. A librar... ...
