Advances in the role of the IGF signaling system in myelodysplastic syndromes and acute myeloid leukemia
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The insulin-like growth factor (IGF) signaling system comprises functionally specific ligands (IGF-I and IGF-II), receptor (IR), and binding proteins (IGFBP). IGFs are activated by binding to their receptor, IGF-IR, which is a tyrosine kinase receptor. This ac... ...
