mTORC1 Selective Nano-Inhibitor by Disrupting the Lysosomal Arginine-SLC38A9- mTORC1-CDKs Axis for Precision Bladder Cancer Therapy
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The absence of precise targeting and defined mechanisms, akin to small molecules, remains a major barrier to the clinical translation of nanomedicines. Mammalian target of rapamycin complex 1 (mTORC1), a key regulator of cell proliferation and metabolism, is l... ...