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Late-onset unexplained epilepsy with dual amyloid and tau negativity: are alpha-synuclein seed amplification assays the next diagnostic step?

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Late-onset epilepsy of unknown etiology (LOEU) is associated with an increased risk of dementia. Current biomarkers, including cerebrospinal fluid (CSF) and positron emission tomography (PET) assessments for amyloid and tau, often fail to predict cognitive dec... ...