Leveraging Complementary Ion Activation Methods with Proton Transfer Charge Reduction Reactions for Comprehensive Characterization of Monoclonal Antibody Heavy Chain Subunits
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Characterization of large proteins by top-down mass spectrometry is challenged by low S/N of fragment ions and spectral congestion. Proton transfer charge reduction (PTCR) is one strategy that has shown great potential for addressing spectral congestion and en... ...
