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Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cells

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Translation initiation in eukaryotes requires a 40 S ribosome loaded with initiator tRNA which scans for an initiation codon. The initiator tRNA is usually recruited to the ribosome as part of a ternary complex composed of initiator tRNA, eIF2, and GTP. Althou... ...