Prevalence and impact of molecular variation in the three-prime repair exonuclease 1 TREX1 and its implications for oncology
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Background: The three-prime repair exonuclease 1, TREX1, degrades cytosolic DNA to prevent aberrant immune activation. Its inactivation results in DNA accumulation in the cytosol and induction of the cGAS-STING DNA sensing pathwa... ...
