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Synthesis, characterization, and biological activity evaluation of 4,6-dihydropyrano[3,2-c]isochromene-3-carbonitrile as anticancer agents

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Herein, a series of new 2-amino-4,6-dihydropyrano[3,2-c]isochromene-3-carbonitrile derivatives (4a-o) have been synthesized by one-pot three component reaction of 4-hydroxyisocoumarin, various aromatic aldehydes, and malononitrile in the presence of triethylam... ...