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Adaptive laboratory evolution of extremophilic red microalga Cyanidioschyzon merolae under high nickel stress enhances lipid production and alleviates oxidative damage

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The extremophilic red microalga Cyanidioschyzon merolae suffers irreversible photosynthetic damage, oxidative stress, and apoptosis when exposed to Ni concentrations above 3 mM. To enhance Ni tolerance, we applied adaptive laboratory evolution (ALE) and develo... ...