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Review Cureus. 2025 May 15;17(5):e84202. doi: 10.7759/cureus.84202 Q21.32025

Preventing Preeclampsia With Low-Dose Aspirin: A Systematic Review of Efficacy Across Diverse Populations

小剂量阿司匹林预防子痫前期的疗效多样性系统评价研究 翻译改进

Rebecca George  1, Zaheeruddin Sayed  2, Hamesh Gundala Raja  3, Asma Qayyum  4, Izmay Ali  5, Noman A Jarang  6, Ishan Solanki  6, Sabiha Ahmad  7, Saba Ahmed  8, Asma Mehdi  9

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作者单位

  • 1 Obstetrics and Gynecology, Malankara Orthodox Syrian Church Medical College, Kolenchery, IND.
  • 2 Internal Medicine, Chandka Medical College, Larkana, PAK.
  • 3 Internal Medicine, K.A.P. Viswanatham Government Medical College, Tiruchirappalli, IND.
  • 4 Obstetrics and Gynecology, Bukayriyah General Hospital, Al-Bukayriyah, SAU.
  • 5 Internal Medicine, Women Medical and Dental College, Abbottabad, PAK.
  • 6 Internal Medicine, Belarusian State Medical University, Minsk, BLR.
  • 7 Gynecology, Zhejiang University, Hangzhou, CHN.
  • 8 Anesthesia and Critical Care, HSE Kerry Community Services, Kerry, IRL.
  • 9 Surgery, Rawalpindi Medical University, Rawalpindi, PAK.
  • DOI: 10.7759/cureus.84202 PMID: 40519374

    摘要 中英对照阅读

    This systematic review evaluates the efficacy of low-dose aspirin (LDA) in preventing preeclampsia in high-risk pregnancies. A comprehensive search of recent randomized controlled trials was conducted, focusing on studies published within the last five years. The review included five studies that investigated LDA at doses ranging from 60 mg to 150 mg, with outcomes measured in diverse populations. Findings indicate that LDA can reduce preeclampsia risk, pa... ...点击完成人机验证后继续浏览

    这项系统综述评估了低剂量阿司匹林(LDA)在高风险妊娠中预防子痫前期的疗效。对最近五年内发表的相关随机对照试验进行了全面检索,纳入的研究共五项,研究对象包括非西班牙裔白人等特定亚组人群,探讨了60毫克至150毫克范围内不同剂量的LDA的效果。结果表明,LDA可以降低子痫前期的风险,但其疗效受阿司匹林抵抗、种族和生物标志物水平等因素的影响。综述还强调了解释阿司匹林作用机制的重要性,特别是抗炎生物标志物如15-epi-lipoxin A4和IL-2的作用。然而,研究之间存在显著的变异,这表明需要采取个性化的预防策略。这项综述强调了未来研究在不同人群中解决阿司匹林疗效差距以及探索基于生物标志物的子痫前期预防策略的重要性。

    关键词: 阿司匹林抵抗; 生物标志物; 高风险妊娠; 低剂量阿司匹林; 个性化医疗; 子痫前期预防; 随机对照试验。

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    期刊名:Cureus journal of medical science

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    ISSN:N/A

    e-ISSN:2168-8184

    IF/分区:1.3/Q2

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    Preventing Preeclampsia With Low-Dose Aspirin: A Systematic Review of Efficacy Across Diverse Populations