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International journal of biological macromolecules. 2025 Jun 13:145226. doi: 10.1016/j.ijbiomac.2025.145226 Q18.52025

Leveraging quality by design for the optimization of polycaprolactone/chitosan nanocomposites loaded with tamoxifen for breast cancer therapy

利用质量设计法优化用于乳腺癌治疗的聚己内酯/壳聚糖纳米复合材料载托瑞米芬研究 翻译改进

Samia Hammouda  1, Rana R Haikal  2, Salma Alawadi  3, Noha El Salakawy  4, Ahmed Abdellatif  5, Wael Mamdouh  6

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作者单位

  • 1 Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address: Samiasalah@aucegypt.edu.
  • 2 Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address: rana.haikal@aucegypt.edu.
  • 3 Department of Biology, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address: Salmaalawadi@aucegypt.edu.
  • 4 Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address: noha2013@aucegypt.edu.
  • 5 Department of Biology, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address: Ahmed.abdellatif@aucegypt.edu.
  • 6 Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, New Cairo 11835, Egypt. Electronic address: wael_mamdouh@aucegypt.edu.

    • DOI: 10.1016/j.ijbiomac.2025.145226 PMID: 40517875

    摘要 中英对照阅读

    With breast cancer being the most common type of cancer among women, novel treatments are still in demand to alleviate the many side effects of conventional therapies. In this study, a Quality by Design (QbD) concept was adopted for the development and optimization of tamoxifen loaded PCl/chitosan nanoparticles (Tam PCL-Cs-NPs) for prolonged release and improved drug solubility and bioavailability. Plackett-Burman design was used to determine the critical ... ...点击完成人机验证后继续浏览

    乳腺癌是女性最常见的癌症类型，因此仍然需要新的治疗方法来减轻传统疗法的许多副作用。在这项研究中，采用质量源于设计（QbD）的概念开发和优化了载有他莫昔芬的聚己内酯/壳聚糖纳米粒子（Tam PCL-Cs-NPs），以实现长效释放并提高药物溶解度和生物利用度。首先使用Plackett-Burman设计确定对所需产品质量属性至关重要的关键参数，然后采用Box-Behnken设计来评估和进一步优化递送系统。优化后的Tam-PCL-Cs-NPs表现出280 nm的小颗粒尺寸和低PDI，并且在两周内实现了持续的药物释放。Tam-PCL-Cs-NPs对癌性的MCF-7和4T1细胞显示出显著更高的细胞毒性，IC50值分别为176.6 μg/mL 和 169.1 μg/mL，而在相同浓度下对非癌性细胞表现出极低的毒性。还评估了Tam-PCL-Cs-NPs的细菌抑制活性，在对抗大肠杆菌和金黄色葡萄球菌时分别在75 μg/mL 和 150 μg/mL 的浓度下观察到最高的抗菌活性。

    关键词：化疗；药物递送；聚己内酯/壳聚糖纳米复合材料。

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    期刊名：International journal of biological macromolecules

    缩写：INT J BIOL MACROMOL

    ISSN：0141-8130

    e-ISSN：1879-0003

    IF/分区：8.5/Q1

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