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Case Reports Current microbiology. 2025 Jun 14;82(8):335. doi: 10.1007/s00284-025-04313-y Q32.62025

Systemic Infection Caused by Mycobacterium fortuitum Following Aortic Valve Transplantation-Employing Combined Molecular Techniques for Accurate Species Identification

冠状动脉移植后诱发的龟分枝杆菌所致全身感染--采用联合分子生物学技术进行准确种属鉴定 翻译改进

Max Roberto Batista de Araújo  1  2, Débora Marques da Silveira E Santos  3, Jailan da Silva Sousa  4, Gerson Fernandes do Prado  5, Diogo Luiz de Carvalho Castro  4, Moacir Soares Dias Júnior  3, Hugo Felix Perini  6, Cíntia Minafra  7, Siomar de Castro Soares  6, Evandro Bento Rodrigues  8  4, Luan Freitas Lana  4, Letícia Aparecida Caldeira Gonçalves  8, Bruno Silva Andrade  9  10, Talita Gomes  4, Vasco Azevedo  4

作者单位 +展开

作者单位

  • 1 Operational Technical Nucleus, Microbiology, Hermes Pardini Institute (Fleury Group), Vespasiano, Minas Gerais, Brazil. max_barau@hotmail.com.
  • 2 Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. max_barau@hotmail.com.
  • 3 Molecular Biology, Operational Technical Nucleus, Hermes Pardini Institute (Fleury Group), Vespasiano, Minas Gerais, Brazil.
  • 4 Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • 5 Hospital Technical Nucleus, Microbiology, Fleury Group, Guarulhos, São Paulo, Brazil.
  • 6 Institute of Biological and Natural Sciences, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
  • 7 School of Veterinary and Animal Science, Food Research Center, Federal University of Goiás, Goiânia, Goiás, Brazil.
  • 8 Operational Technical Nucleus, Microbiology, Hermes Pardini Institute (Fleury Group), Vespasiano, Minas Gerais, Brazil.
  • 9 Laboratory of Bioinformatics and Computational Chemistry, State University of Southwest Bahia, Jequié, Bahia, Brazil.
  • 10 INRAE, Institut Agro, STLO, Rennes, France.

    • DOI: 10.1007/s00284-025-04313-y PMID: 40515850

    摘要 中英对照阅读

    Mycobacterium fortuitum, a nontuberculous mycobacterium (NTM), is known for causing opportunistic infections, particularly in immunocompromised individuals. Identification of NTM species requires precise diagnostic techniques. Here, we present a study of a systemic infection by M. fortuitum in an elderly patient, identified through MALDI-TOF MS and confirmed by gene sequencing. An 88-year-old Italian man developed an abscess at his pacemaker site, leading ... ...点击完成人机验证后继续浏览

    分枝杆菌属的 opportunistica（Mycobacterium fortuitum）是一种非结核分枝杆菌（NTM），常引起机会性感染，特别是在免疫功能低下的个体中。鉴定 NTM 物种需要精确的诊断技术。在此，我们介绍了一位老年患者因 M. fortuitum 引起的全身感染的研究案例，该病例通过 MALDI-TOF 质谱分析确认，并通过基因测序进一步证实。一位88岁的意大利男性在心脏起搏器部位出现脓肿，导致由表皮葡萄球菌（Staphylococcus capitis）引发的急性感染性心内膜炎。住院期间，他经历了多种并发症，包括颈静脉血栓、肺部血栓栓塞和胃肠道出血。尽管使用万古霉素治疗，但他仍然出现了败血症，从血液培养中分离出了 M. fortuitum。通过 MALDI-TOF 质谱分析并结合 16S rRNA 和 hsp65 基因的 Sanger 测序确认了该菌株的鉴定结果。系统发育分析支持此鉴定结论。患者在接受碳青霉烯类和氨基糖苷类药物治疗后返回意大利，没有出现进一步的临床并发症。本案例强调了精确诊断工具在管理 NTM 感染中的必要性。结合应用 MALDI-TOF 质谱分析和基因测序能够准确鉴定物种，在免疫抑制等复杂临床情况下有效指导 M. fortuitum 全身感染的治疗。

    © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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    期刊名：Current microbiology

    缩写：CURR MICROBIOL

    ISSN：0343-8651

    e-ISSN：1432-0991

    IF/分区：2.6/Q3

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    Systemic Infection Caused by Mycobacterium fortuitum Following Aortic Valve Transplantation-Employing Combined Molecular Techniques for Accurate Species Identification