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Oral Cryotherapy for the Prevention of Oral Mucositis in Children With Hematolymphoid Malignancies Receiving IV Methotrexate-Based Chemotherapy: A Randomized Controlled Trial

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Background and aims: Oral mucositis (OM) is a debilitating adverse effect of many chemotherapeutic drugs. Oral cryotherapy using ice cubes/chips is used to prevent oral mucositis in adults post 5-fluorouracil (5-FU)/melphalan adm... ...