Lasers in medical science. 2025 Jun 13;40(1):278. doi: 10.1007/s10103-025-04508-6 Q12.42025

Ten-year outcomes of effective optical zone and decentration analysis after keratorefractive lenticule extraction for moderate and high myopia

角膜基质透镜取出术矫正中高度近视10年视觉及光学效果分析翻译改进

Tianze Cui^{1 2}, Yangyi Huang^{1 2}, Fei Xia^{1 2}, Zhuoyi Chen^{1 2}, Meiyan Li^{1 2}, Xingtao Zhou^{3 4}, Xiaomei Qu^{5 6}

作者单位 +展开

作者单位

¹ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Fudan, China.

² NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China.

³ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Fudan, China. doctzhouxingtao@163.com.

⁴ NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. doctzhouxingtao@163.com.

⁵ Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Fudan, China. quxiaomei2002@126.com.

⁶ NHC Key Laboratory of Myopia (Fudan University); Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China. quxiaomei2002@126.com.

DOI: 10.1007/s10103-025-04508-6 PMID: 40512302

摘要中英对照阅读

To investigate ten-year changes in the effective optical zone (EOZ) and decentration after keratorefractive lenticule extraction (KLEx) for moderate and high myopia. In this prospective study, 27 patients (48 eyes, spherical equivalent: -6.34 ± 1.19 D) were enrolled and treated with KLEx. Follow-up was conducted 10 years postoperatively. The EOZ and decentration were calculated using custom software based on the tangential corneal curvature maps. The relationships among keratometry, corneal wavefront aberrations, EOZ, and decentration were evaluated. Ten years postoperatively, the safety and efficacy indexes were 1.14 ± 0.19 and 1.05 ± 0.25, respectively. The EOZ diameter was 5.31 ± 0.26 mm. In the longitudinal analysis, the percentages of (1-EOZ/POZ) were 31.02 ± 1.02%, 31.14 ± 1.08%, 33.22 ± 1.06%, and 34.91 ± 1.02% at postoperative 1 month, 1 year, 5 years, and 10 years. The differences between preoperative and postoperative higher-order aberrations (HOAs) were 0.23 ± 0.02 μm, 0.24 ± 0.02 μm, 0.21 ± 0.02 μm, 0.17 ± 0.02 μm. The factors influencing the EOZ percentages were time (p = 0.002), correction cylinders (p = 0.005), and interaction between correction cylinders and spheres (p = 0.014), and the factors influencing HOAs inductions were time (p = 0.001), scotopic pupil (p = 0.001), postoperative decentration (p < 0.001), EOZ diameter (p = 0.030), and the interaction between decentration and EOZ diameter (p = 0.002). The decentration was 0.39 ± 0.15 mm at the last follow-up, which was statistically unchanged throughout the follow-up. KLEx is safe and effective for patients with moderate or high myopia in the long term. The EOZ decreased slightly but was broadly stable, and the decentration remained stable during the 10-year follow-up.

Keywords: Decentration; Effective optical zone; Higher-order aberrations; Keratorefractive lenticule extraction; Myopia.

Keywords：optical zone analysis; decentration analysis

研究十年间角膜屈光透镜切除术（KLEx）治疗中高度近视后有效光学区域（EOZ）和偏心变化的情况。在这项前瞻性研究中，共纳入27名患者（48只眼睛，等效球镜度：-6.34 ± 1.19 D），并在其术后十年进行随访。使用基于角膜切线曲率图的定制软件计算EOZ和偏心情况。评估了屈光度、角膜波前像差、EOZ以及偏心之间的关系。术后十年，安全性和有效性指数分别为1.14 ± 0.19 和 1.05 ± 0.25。EOZ直径为5.31 ± 0.26 mm。纵向分析显示，术后一个月、一年、五年和十年的（1-EOZ/POZ）百分比分别是31.02 ± 1.02%、31.14 ± 1.08%、33.22 ± 1.06% 和 34.91 ± 1.02%。术后与术前高阶像差（HOAs）的变化值分别为0.23 ± 0.02 μm、0.24 ± 0.02 μm、0.21 ± 0.02 μm 和 0.17 ± 0.02 μm。影响EOZ百分比的因素有时间（p = 0.002）、矫正柱镜（p = 0.005）和矫正柱镜与球镜之间的交互作用（p = 0.014），而影响HOAs产生的因素包括时间（p = 0.001）、暗瞳直径（p = 0.001）、术后偏心（p

关键词： 偏心；有效光学区域；高阶像差；角膜屈光透镜切除术；近视。

关键词：角膜屈光性透镜取出术

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