Exercise tolerance prior to hematopoietic stem cell transplantation (HSCT) is an important prognostic indicator. Nevertheless, patients with acute lymphocytic leukemia (ALL) before HSCT have reduced exercise tolerance after multiple rounds of chemotherapy. Exercise is encouraged in these patients to prevent reduced exercise tolerance. However, exercise compliance is reduced during chemotherapy. Therefore, we focused on the potential role of high-intensity interval training (HIIT), which improves exercise tolerance but requires fewer interventions. The efficacy and safety of HIIT in patients undergoing chemotherapy remain unknown. Here, we report an exercise intervention that incorporated HIIT in a patient with ALL undergoing consolidation chemotherapy (CC). The patient was a 40-year-old female diagnosed with ALL for whom rehabilitation was implemented after initiation of induction chemotherapy. The patient underwent aerobic exercise on an ergometer (20 min at 50-60% intensity, using the Karvonen method) and weight-bearing resistance training (three sets of 10-20 repetitions at a 4-5 rating on the modified Borg scale) five times a week. The physical function assessment before the third CC session showed decreased exercise tolerance. An HIIT intervention was added as a more effective rehabilitation strategy for the patient. HIIT was performed on an ergometer. The protocol consisted of a 5-min warm-up, three to four sets of alternating between 80-90% peak oxygen uptake (peak VO₂) and anaerobic threshold (AT) load for 3 min, and a 5-min cool-down. The number of HIIT interventions was nine of the 21 scheduled for rehabilitation. When HIIT was difficult, aerobic exercise was performed using an ergometer. Exercise tolerance improved without any adverse events, including bleeding, during rehabilitation. In conclusion, practicing HIIT sessions in patients receiving CC appears to safely enhance exercise tolerance with minimal intervention.

Keywords: acute lymphoblastic leukemia; consolidation chemotherapy; hematopoietic stem cell transplantation; high-intensity interval training; rehabilitation.

Copyright © 2025, Hanajima et al.

在造血干细胞移植（HSCT）前的运动耐受力是一个重要的预后指标。然而，在接受多轮化疗之前，急性淋巴细胞白血病（ALL）患者表现出降低的运动耐受力。鼓励这些患者进行锻炼以预防运动耐受力下降，但化疗期间患者的锻炼依从性较低。因此，我们关注高强度间歇训练（HIIT）在改善运动耐受力方面的潜在作用，因为HIIT需要较少的干预措施。然而，在接受化疗的患者中使用HIIT的有效性和安全性尚不清楚。在这里，我们报告了一位正在接受巩固化疗（CC）期间进行ALL康复治疗患者的锻炼干预情况。该患者为一名40岁女性，被诊断出患有急性淋巴细胞白血病，并在诱导化疗开始后实施了康复计划。患者每周五次进行了有氧运动和抗阻训练。有氧运动是在功率自行车上进行的（使用Karvonen方法，在20分钟内以50-60%强度），而抗阻训练是负重练习，每次三组，每组10-20次重复动作，采用改良Borg量表评估为4-5级。在第三次CC疗程前对患者的体能进行了评估，发现其运动耐受力下降。因此，为了给患者提供更有效的康复策略，我们增加了一项HIIT干预措施。这项HIIT是在功率自行车上进行的，包括一个5分钟的热身、三到四组交替使用80-90%峰值摄氧量（peak VO₂）和无氧阈值（AT）负荷各3分钟的过程以及一个5分钟的冷却阶段。在计划中的21次康复治疗中，HIIT干预措施进行了九次。当进行HIIT困难时，患者将使用功率自行车进行有氧运动。在整个康复过程中，患者的运动耐受力得到改善，并且没有出现包括出血在内的不良事件。总之，在接受巩固化疗的患者中实践HIIT似乎可以安全地增强其运动耐受力，而只需最少的干预措施。

关键词：急性淋巴细胞白血病；巩固化疗；造血干细胞移植；高强度间歇训练；康复治疗。