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Injury. 2025 Jun 3:112514. doi: 10.1016/j.injury.2025.112514 Q22.02025

A prospective multi-site cohort study on the prevalence of frailty in patients aged over 70 years presenting after serious injury and implications for outcomes

一项针对严重受伤的70岁以上患者进行的前瞻性多中心队列研究:脆弱性的患病率及其对预后的影响 翻译改进

Anthony P Joseph  1, Bonnie M Liu  2, Martie Botha  3, Elizabeth Wake  4, James E Hardy  5, Bhavik Patel  6, Sarah N Hilmer  7

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作者单位

  • 1 Discipline of Emergency Medicine, Faculty of Medicine and Health. University of Sydney NSW, Australia. Electronic address: apjoseph53@gmail.com.
  • 2 Department of Aged Care, Royal North Shore Hospital, St Leonard NSW Australia; Kolling Institute, Northern Sydney Local Health District and The University of Sydney, Australia. Electronic address: Bonnie.Liu@health.nsw.gov.au.
  • 3 Trauma Service, Royal Adelaide Hospital, Adelaide, Australia. Electronic address: Martie.Botha@sa.gov.au.
  • 4 Trauma Service, Gold Coast University Hospital, Southport, Queensland, Australia, School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Australia. Electronic address: elizabeth.wake@health.qld.gov.au.
  • 5 Department of Aged Care, Royal North Shore Hospital, St Leonard NSW Australia. Electronic address: james.hardy@health.nsw.gov.au.
  • 6 Trauma Service, Gold Coast University Hospital, Southport, Queensland, Australia. Electronic address: Bhavik.Patel@health.qld.gov.au.
  • 7 Department of Aged Care, Royal North Shore Hospital, St Leonard NSW Australia; Kolling Institute, Northern Sydney Local Health District and The University of Sydney, Australia. Electronic address: sarah.hilmer@sydney.edu.au.
  • DOI: 10.1016/j.injury.2025.112514 PMID: 40506331

    摘要 中英对照阅读

    Introduction: Major Trauma Hospitals are receiving increasing numbers of older patients after serious injury. Outcomes in these patients vary with the nature of the injury and other factors such as frailty. We aimed to determine the prevalence of frailty and adverse events in older patients managed by acute trauma services during the index hospital admission, and the frequency of adverse outcomes at three, six and twelve months after discharge in an Australian setting.

    Methodology: This study assessed the prevalence of frailty in a prospective multicentre cohort study of seriously injured patients aged ≥ 70 years admitted to three Major Trauma Services in Australia. Patients were followed for twelve months after injury to assess for adverse outcomes associated with the presence of frailty or other factors. During the index admission patients were assessed for frailty, co-morbidities, Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs). Patients were monitored for adverse events and whether a Geriatrician review occurred. Outcomes assessed at three, six and twelve months included increased dependency, falls, confusion, readmission to hospital, transfer to a Residential Aged Care Facility and death.

    Results: 217 patients were recruited between 2018 and 2023 across the three hospitals. At index admission, 32 (14.7%) patients were frail and another 28 (12.9%) were near frail. Geriatrician review was more likely for frail patients and there were similar rates of inpatient complications for both frail and non-frail patients. Frailty at index admission was associated with increased dependency, falls, readmission and confusion at three, six and twelve months and with an increased risk of death at three and six months.

    Conclusions: Frailty was associated with delayed adverse outcomes up to 12 months following admission for serious trauma in older people at three major Australian trauma services. Assessment of frailty on admission may be useful in stratifying outcome risk for older patients. Further research into frailty interventions and pathways is recommended.

    Keywords: Adverse events; Frailty; Major trauma; Older patients; Outcomes.

    Keywords:prospective cohort study; frailty; older adults; serious injury; outcomes

    介绍:严重受伤的老年患者在主要创伤医院的就诊人数不断增加。这些患者的预后因伤害性质及其他因素(如衰弱)而异。我们的目标是确定由急性创伤服务管理的老年患者在首次住院期间衰弱和不良事件的发生率,并评估出院后三个月、六个月和十二个月的不良结果频率,研究背景为澳大利亚。

    方法:本研究对2018年至2023年间入院并接受来自澳大利亚三家主要创伤服务的70岁及以上严重受伤患者进行了前瞻性多中心队列研究,评估其衰弱的流行率。在受伤后随访十二个月以评估与衰弱或其它因素相关的不良结果。首次住院期间,对患者的衰弱、共病情况、日常生活活动(ADL)和工具性日常生活活动(IADL)进行评估,并监测是否出现不良事件以及是否进行了老年医学科会诊。在三个月、六个月和十二个月时的预后评估包括增加依赖性、跌倒、混乱状态、再次入院、转移到养老照护设施及死亡。

    结果:2018年至2023年间,有217名患者在三家医院中被纳入研究。首次住院时,32(14.7%)名患者为衰弱状态,另有28(12.9%)名患者接近衰弱状态。衰弱患者的会诊老年医学科的概率更高,并且对于衰弱和非衰弱的在院患者并发症发生率相当。首次住院时即为衰弱状态与三个月、六个月及十二个月期间增加依赖性、跌倒、再次入院和混乱状态相关,同时增加了前三个月和前六个月内死亡的风险。

    结论:在澳大利亚三家主要创伤服务中,严重受伤的老年患者首次住院后的12个月内,衰弱与延迟出现的不良结果有关。入院时评估衰弱可能有助于对老年患者的预后风险进行分层。建议进一步研究衰弱干预和路径。

    关键词:不良事件;衰弱;重大创伤;老年患者;预后。

    关键词:前瞻性队列研究; 衰弱; 老年人; 严重伤害; 结局指标

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    期刊名:Injury-international journal of the care of the injured

    缩写:INJURY

    ISSN:0020-1383

    e-ISSN:1879-0267

    IF/分区:2.0/Q2

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