Stroke is the leading-cause of death in women and motor-disability in adults. In patients with diabetes, diabetic peripheral neuropathy (DPN) increases the risk of ischemic stroke. The aim of this work was to test the hypothesis that an etiological pattern of ischemic stroke in patients with DPN can be recognized. This was a single-center retrospective observational study of patients hospitalized in Cayenne general-hospital with ischemic stroke. The primary endpoint was to determine if there is an association between the mechanism of stroke and the presence of DPN. We included 226 patients: mean age 64.14±15.2 years; male predominance (62.4%); and 5.8% with DPN, i.e. 14.9% of patients with diabetes. DPN was significantly associated with small-vessel disease (SVD): adjusted odds ratio=5.08 [1.17;22.14]. These findings highlight a common pathophysiology between DPN and SVD. DPN can provide a window of opportunity to detect SVD and prevent its complications like stroke or dementia.

Keywords: Diabetes; Diabetic peripheral neuropathy; Small-vessel disease; Stroke.

Copyright © 2025. Published by Elsevier Masson SAS.

中风是女性死亡的主要原因，也是成人运动障碍的主要原因。对于糖尿病患者来说，糖尿病周围神经病变（DPN）增加了缺血性卒中的风险。本研究的目的是检验以下假设：在患有 DPN 的患者中可以识别出一种病因模式的缺血性卒中。这项研究是在卡宴总医院住院的缺血性卒中患者进行的一项单中心回顾性观察研究。主要终点是确定卒中的发病机制与DPN的存在之间是否存在关联。我们纳入了226名患者：平均年龄为64.14±15.2岁；男性占多数（62.4%）；其中有 5.8% 的 DPN，即糖尿病患者的 14.9%。DPN 显著与小血管疾病 (SVD) 相关：调整后的比值比=5.08 [1.17;22.14]。这些发现强调了 DPN 和 SVD 在病理生理上的共通性。DPN 可以为检测 SVD 提供一个窗口，从而预防中风或痴呆等并发症。

关键词：糖尿病；糖尿病周围神经病变；小血管疾病；卒中。

版权 © 2025. 出版方：Elsevier Masson SAS.