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A Comparative Study of Bone Marrow and Central Nervous System Microenvironment Models to Improve In Vitro Studies of Acute Lymphoblastic Leukemia

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The bone marrow (BM) niche plays a critical role in the development of acute lymphoblastic leukemia (ALL), while the central nervous system (CNS) is a common site of dissemination. Existing in vitro models of childhood ALL lack complexity and fail to recapitul... ...