Objective: Learned helplessness syndrome is a psychological condition where individuals learn that their actions have no effect on outcomes. This phenomenon can be influenced by various environmental factors, including noise. The relationship between the harmful neurological effects of noise and learned helplessness syndrome has not been studied yet. This subject was investigated.

Methods: Thirty-two healthy Sprague-Dawley rats were divided into three groups: The control group (G-I, n = 6), the low-level noise exposure group (80 dB, G-II, n = 10), and the high-level noise exposure group (100 dB, G-III, n = 16). Animals were exposed to impulse noise. Resistance score (RS) was designed as no reaction (0P), alertness (1P), staying away from the source of the sound (2P), fussiness (3P), crowding up (4P), trying to escape from cages (5P), biting the bars (6P), and hair loss and self injury (7P).

Results: After decapitation, the degenerated neuron densities of the amygdala were compared with RS values. The RS scores of rats were changed from 0-6 in G-I, 6-15 in G-II, and 10-28 in G-III. The apoptotic neuron density of the amygdala was estimated as 12 ± 4/mm3 in G-I (p > 0.5), 231 ± 56/mm3 in G-II (p < 0.005), and 1143 ± 102/mm3 in G-III (p < 0.0005).

Conclusion: The animals with a higher RS score (>21) showed less neuronal apoptosis than animals with a lower RS score. In conclusion, this study indicates that the noise exposure-related neurodegeneration of the amygdala in rats may cause 'learned helplessness' syndrome.

Keywords: Noise; amygdala; degeneration; learned helplessness syndrome; sound.

目的： 习得性无助综合征是一种心理状况，个体认为他们的行为对结果没有影响。这一现象可以受到各种环境因素的影响，包括噪声。噪音的有害神经效应与习得性无助综合征之间的关系尚未被研究过。该主题进行了调查。

方法： 将32只健康的Sprague-Dawley大鼠分为三组：对照组（G-I, n = 6），低水平噪声暴露组（80 dB，G-II，n = 10）和高水平噪声暴露组（100 dB，G-III，n = 16）。动物接受脉冲噪声的暴露。抵抗力评分（RS）被设计为无反应（0分）、警觉性（1分）、远离声音来源（2分）、烦躁不安（3分）、聚集在一起（4分）、试图从笼子里逃跑（5分）、咬笼子栏杆（6分），以及掉毛和自我伤害（7分）。

结果： 在处死后，与RS值相比，杏仁体中退化神经元的密度进行了比较。G-I组大鼠的RS评分从0-6变化，G-II组为6-15，而G-III组则为10-28。G-I组（p > 0.5）的杏仁体细胞凋亡密度估计为每立方毫米12 ± 4个细胞，G-II组（p

结论： 具有较高RS评分（>21）的大鼠表现出较少的神经元凋亡，而RS评分较低的大鼠神经元凋亡较多。总之，这项研究表明，在大鼠中，与噪声暴露相关的杏仁体退化可能会导致“习得性无助”综合征。

关键词： 噪音；杏仁体；退行性病变；习得性无助症候群；声音。