A streamlined radiosynthetic methodology enables the precise sequential assembly of boronic ester precursors on diol resin, seamlessly integrating copper-mediated radioiododeboronation and azide-alkyne cycloaddition. This approach yields radioiodinated compounds with high radiochemical conversion (>90%) without requiring column purification until the final stage, thereby accelerating the efficient development of advanced radioiodinated molecular probes.
The Journal of organic chemistry. 2025 Jun 9. doi: 10.1021/acs.joc.5c00382
Sequential Radiosynthetic Methodology: Assembly of Boronic Ester Precursors on a Diol Resin and Radioiodination Using Copper-Mediated Radioiododeboronation and Azide-Alkyne Cycloaddition
序贯放射合成法：在二醇树脂上装配硼酸酯前体，并通过铜介导的放射性碘脱硼化和叠氮-炔环加成进行放射性碘标记 翻译改进
作者单位 +展开
作者单位
DOI: 10.1021/acs.joc.5c00382 PMID: 40490409
摘要 中英对照阅读
相关内容
-
Apparent copper(II)-accelerated azide-alkyne cycloaddition
看似被铜(II)加速的叠氮-炔环加成反应
Organic letters. 2009 Nov 5;11(21):4954-7.
-
A facile route to viologen functional macromolecules through azide-alkyne [3+2] cycloaddition
通过叠氮炔烃环加成方便地制备双芳基乙烯功能高分子路线
Macromolecular rapid communications. 2013 Oct;34(19):1547-53.
-
Azide alkyne cycloaddition facilitated by hexanuclear rhenium chalcogenide cluster complexes
六核铼硫属元素簇配合物促进的叠氮炔烃环加成反应
Dalton transactions (Cambridge, England : 2003). 2013 Jun 14;42(22):8132-9.
-
Regiodivergent Rhodium(I)-Catalyzed Azide-Alkyne Cycloaddition (RhAAC) To Access Either Fully Substituted Sulfonyl-1,2,3-triazoles under Mild Conditions
温和条件下通过区域选择性铑催化炔氢-叠氮加成反应合成位阻较大的磺酰基-1,4-和-1,5-三唑化合物
Organic letters. 2018 Nov 2;20(21):6705-6709.
-
Copper phosphorylated cellulose nanofibers mediated azide-alkyne cycloaddition click reaction in water
铜磷化纤维素纳米纤维介导的水相叠氮𬭩-炔烃环加成点击反应
Carbohydrate polymers. 2024 Jan 15:324:121501.
-
The effects of ionic liquids on azide-alkyne cycloaddition reactions
离子液体对叠氮化物-炔烃环加成反应的影响
Organic & biomolecular chemistry. 2010 Dec 7;8(23):5354-8.
-
The reaction mechanism of the azide-alkyne Huisgen cycloaddition
叠氮炔𬭩环加成反应的机理研究
Physical chemistry chemical physics : PCCP. 2019 Sep 11;21(35):19281-19287.
-
Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism
钌催化叠氮-炔烃环加成反应：作用范围与机制研究
Journal of the American Chemical Society. 2008 Jul 16;130(28):8923-30.
-
Cu-catalyzed azide-alkyne cycloaddition
铜催化的叠氮-炔环加成反应
Chemical reviews. 2008 Aug;108(8):2952-3015.