PeerJ. 2025 Jun 4:13:e19502. doi: 10.7717/peerj.19502 Q22.42025
Associations between maternal glycemic level and lipid profile and adverse pregnancy outcomes in women with type 2 diabetes mellitus: a retrospective study from China
中国2型糖尿病孕妇血糖水平和血脂谱与不良妊娠结局的相关性:一项回顾性研究 翻译改进
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DOI: 10.7717/peerj.19502 PMID: 40487056
摘要 中英对照阅读
目的:
探讨妊娠期血糖和脂质代谢与2型糖尿病(T2DM)孕妇不良妊娠结局之间的关联。
方法:
纳入在北京大学第一医院分娩的T2DM孕妇,采用单变量和多变量逻辑回归分析识别风险因素。应用ROC曲线确定预测不良妊娠结局的最佳临界值。
结果:
从2019年到2023年共纳入了398对孕产妇及其新生儿。主要并发症包括巨大儿(LGA,21.6%)、子痫前期(PE,14.3%)、早产(14.3%)和出生缺陷(11.6%)。早期妊娠期间糖化血红蛋白A1c(HbA1c)和脂质水平的达标率约为50%。晚期妊娠期间较高的HbA1c与增加的新生儿体重显著相关(对于LGA,调整后的比值比aOR = 3.819,95% CI [1.534-9.509])。早期妊娠期甘油三酯(TG)水平升高是LGA、PE和早产的重要风险因素(aOR分别为2.627、2.478、2.233;所有p值均
结论:
在中国T2DM孕妇中,不同孕期阶段升高的血糖和脂质水平与不良妊娠结局独立相关,尤其是晚期妊娠HbA1c和早期妊娠TG。降低早孕期甘油三酯水平可能有助于改善不良妊娠结局。
关键词:
不良妊娠结局;糖化血红蛋白(HbA1c);脂质谱;孕前糖尿病。
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