Introduction: The Carpal tunnel syndrome (CTS) is a frequent cause of hand symptoms and activity limitations, which is associated with various personal risk factors. However, the association between these risk factors and CTS under conditions of cumulative exposure to the risk factors remains unclear.

Method: In this study, we utilized a cumulative risk score to assess the prevalence level of CTS , and further evaluated the interactions between different risk factors and their cumulative association with CTS. Specifically, we first conducted a univariate regression analysis to evaluate the independent association of risk factors with CTS. Then we ran the multivariate regression model to filter out significant risk factors from risk factors associated with CTS. Next, we constructed the risk score to represent the cumulative association of significant risk factors with CTS, and we analyzed the relationship between the risk score and the prevalence level of CTS.

Results: The experiment results demonstrated that among the various personal factors, sex, age, BMI, sleep disorder, smoking frequency, restlessness, diabetes, kidney failure, arthritis, and joint pain were the most significant factors related to CTS. There existed the cumulative association of risk factors with CTS, and the cumulative association of risk factors was positively related with an increased prevalence level of CTS. Moreover, there existed a critical threshold (risk score = 3) for the increase in the prevalence level of CTS.

Conclusions: Our study reveals the significant risk factors among personal factors related with CTS, and presents the cumulative association of these risk factors with CTS. Moreover, we offer the actionable suggestions for CTS prevention based on the experiment results.

Practical applications: The occurrence of CTS is associated with various risk factors. Identifying the independent and cumulative association of different risk factors is essential for designing effective preventive measures and interventions for CTS. Therefore, this study could be important for health management in CTS and other similar diseases.

Keywords: Carpal tunnel syndrome; Cumulative association assessment; Personal risk factors.

Copyright © 2025 National Safety Council and Elsevier Ltd. All rights reserved.

简介： 腕管综合征（CTS）是手部症状和活动受限的常见原因，与各种个人风险因素相关。然而，在累积暴露于这些风险因素的情况下，这些风险因素与CTS之间的关联仍不清楚。

方法： 在这项研究中，我们使用累积风险评分来评估CTS的流行程度，并进一步评价不同风险因素之间以及它们与CTS的累积关联。具体而言，我们首先进行了单变量回归分析以评估风险因素与CTS之间的独立关联。然后运行多变量回归模型从与CTS相关的风险因素中筛选出显著的风险因素。接着，我们构建了风险评分来表示显著风险因素与CTS之间的累积关联，并分析了风险评分和CTS流行程度之间的关系。

结果： 实验结果显示，在各种个人因素中，性别、年龄、BMI、睡眠障碍、吸烟频率、易激动性、糖尿病、肾功能衰竭、关节炎以及关节疼痛是与CTS最相关的显著因素。风险因素与CTS之间存在累积关联，并且风险因素的累积关联与CTS流行程度增加呈正相关关系。此外，在CTS流行程度增加方面，存在一个临界阈值（风险评分 = 3）。

结论： 我们的研究揭示了与CTS相关的个人因素中的显著风险因素，并展示了这些风险因素与CTS之间的累积关联。此外，我们根据实验结果提出了预防CTS的可行建议。

实际应用： CTS的发生与各种风险因素有关。确定不同风险因素之间独立和累积的关联对于设计有效的预防措施和干预措施至关重要。因此，这项研究对CTS和其他类似疾病的健康管理可能非常重要。

关键词： 腕管综合征；累积关联评估；个人风险因素。