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Multiple sclerosis and related disorders. 2025 May 28:100:106555. doi: 10.1016/j.msard.2025.106555 Q22.92024

A longitudinal investigation of the cerebral venous hemodynamics in multiple sclerosis using computational fluid dynamics

基于计算流体动力学的多发性硬化病脑静脉血流动态研究 翻译改进

Alexander Robert Bateman  1, Jeannette Lechner-Scott  2, Tracie Barber  3, Grant Alexander Bateman  4, Saadallah Ramadan  5, Rodney Lea  6

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作者单位

  • 1 School of Mechanical Engineering, University of New South Wales, Sydney, NSW, Australia; Discipline of Aerospace, Mechanical and Mechatronics Engineering, School of Engineering, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW, Australia. Electronic address: alexander.bateman@unsw.edu.au.
  • 2 School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Department of Neurology, John Hunter Hospital, Newcastle, Australia; Hunter Medical Research Institute, Newcastle, Australia.
  • 3 School of Mechanical Engineering, University of New South Wales, Sydney, NSW, Australia.
  • 4 School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Department of Medical Imaging, John Hunter Hospital, Newcastle, NSW, Australia.
  • 5 School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Hunter Medical Research Institute, Newcastle, Australia.
  • 6 School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia; Centre for Genomics and Personalised Health, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.

    • DOI: 10.1016/j.msard.2025.106555 PMID: 40480032

    摘要 中英对照阅读

    Background: The cerebral venous system may influence the development of multiple sclerosis; however, this has not yet been fully investigated. This study aims to assess if the hemodynamics of the cerebral venous system in participants who are living with multiple sclerosis changes over time and if this system appears to affect the development of multiple sclerosis (MS).

    Methods: 13 participants living with MS had MRIs approximately 5 years apart, from which the patient-specific vascular geometry and blood flow were determined. Computational fluid dynamics models were then created and simulated for each patient and compared to 10 controls.

    Results: The straight sinus (ST) blood flow in the initial MS group was increased compared to the controls and showed a trend of decreasing flow at follow-up. The distal sinuses appeared to increase in size over time despite the pressure drop within them decreasing. The expanded disability status scale (EDSS) was found to correlate with a decrease in ST pressure drop and vascular resistance.

    Conclusion: The findings of this study suggest that changes in the cerebral venous system could potentially be related to the pathophysiology of MS, however, further investigation is required.

    Keywords: Cerebral venous system; Computational fluid dynamics; Hemodynamics; Multiple sclerosis; Vascular resistance; Venous elasticity.

    Keywords：cerebral venous hemodynamics; multiple sclerosis; computational fluid dynamics

    背景： 脑静脉系统可能会影响多发性硬化症的发展，然而这一方面尚未得到充分研究。本研究旨在评估在患有多发性硬化症的参与者中，脑静脉系统的血流动力学是否随时间发生变化以及该系统是否会对其发展产生影响。

    方法： 13名患有MS的参与者分别间隔约5年进行了MRI扫描，从中确定了每位患者特异性的血管几何结构和血液流动。然后为每个患者创建并模拟了计算流体动力学模型，并与10个对照组进行比较。

    结果： 初始MS组的直窦（ST）血流量相较于对照组增加了，在随访中显示出减少的趋势。尽管远端窦内的压力下降，但这些窦似乎会随着时间的增长而增大。扩展残疾状况量表（EDSS）被发现与ST压力下降和血管阻力降低呈相关性。

    结论： 本研究的发现表明脑静脉系统的改变可能与多发性硬化症的病理生理学有关，但需要进一步的研究。

    关键词： 脑静脉系统；计算流体动力学；血流动力学；多发性硬化症；血管阻力；静脉弹性。

    关键词：脑静脉血流动力学; 多发性硬化症; 计算流体动力学

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    期刊名：Multiple sclerosis and related disorders

    缩写：MULT SCLER RELAT DIS

    ISSN：2211-0348

    e-ISSN：2211-0356

    IF/分区：2.9/Q2

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