Background: The National Drug Early Warning System Rapid Street Reporting study monitors over 100 drugs to identify emerging use trends.

Objectives: This analysis examined geographical differences in the past 12-month self-reported drug use across 20 US urban cities, identifying the three most prevalent drugs reported, excluding alcohol.

Methods: Adults (age ≥18) were surveyed in public settings using venue-intercept sampling over a weekend in each city between January 2022 and November 2023 regarding past 12-month drug use. We focused on the three most commonly reported drugs in each region. The prevalence of reported drug use by region was compared using generalized linear models with Poisson and log-link functions, adjusting for participant characteristics, time of year, and location.

Results: Among 6,039 participants, cannabis for recreational use (50.3%), psilocybin (13.7%), and cocaine (11.0%) were the most commonly reported drugs used. While there were no regional differences in the prevalence of recreational cannabis use, psilocybin, and cocaine use were more commonly reported by people in the West versus the Midwest (adjusted prevalence ratio [aPR]=1.58, 95% confidence interval [CI]: 1.23, 2.06; aPR=1.67, 95% CI: 1.26, 2.23, respectively). We also found a higher prevalence of cocaine use reported by participants in the Northeast compared to participants in the Midwest (aPR=1.37, 95% CI: 1.00, 1.91).

Conclusions: Venue intercept survey method detected signals of recreational cannabis, psilocybin, and cocaine use in the 20 US urban cities visited over a weekend. Reported prevalence differed by region. This suggests that prevention messaging should be tailored to the specific US regions.

Keywords: Rapid surveys; cannabis; cocaine; geographical differences; psilocybin; region.

背景：

国家药物早期预警系统快速街面报告研究监控超过100种药物，以识别新兴使用趋势。

目标：

本分析调查了20个美国城市过去12个月自我报告的药物使用的地理差异，并确定除酒精外最常见的三种上报药物。

方法：

在2022年1月至2023年11月期间，研究人员在每个城市的周末，在公共场所使用现场拦截抽样法对年龄≥18岁的成人进行调查，询问其过去12个月内的药物使用情况。我们重点关注各地区最常见的三种上报药物。通过广义线性模型（采用泊松分布和对数链接函数），并根据参与者特征、年份时间以及地点调整后，比较了不同地区的报告药物使用的流行率。

结果：

在6,039名参与者中，用于娱乐的可卡因（50.3%）、裸盖菇素（13.7%）和可卡因（11.0%）是最常见的上报使用药物。尽管娱乐性大麻使用的流行率没有地区差异，但西区与中西部相比，裸盖菇素和可卡因的使用报告更为普遍（调整后的流行比[aPR]=1.58, 95%置信区间[CI]: 1.23, 2.06；aPR=1.67, 95% CI: 1.26, 2.23）。我们还发现，东北部地区的参与者报告的可卡因使用频率高于中西部地区（aPR=1.37, 95% CI: 1.00, 1.91）。

结论：

现场拦截调查方法检测到20个美国城市在周末娱乐性大麻、裸盖菇素和可卡因使用的信号。报告的流行率存在地区差异，这表明预防信息应针对特定的美国区域进行调整。

关键词：

快速调查；大麻；可卡因；地理差异；裸盖菇素；地区。