Review Current microbiology. 2025 Jun 3;82(7):322. doi: 10.1007/s00284-025-04279-x Q32.62025
Prospects of Synthetic Biology-Based Approaches in the Enhanced Production of Pyocyanin in Pseudomonas aeruginosa MCCB 117 as the Drug of Choice in Aquaculture
天蓝色吡喃素的增产及其作为水产养殖理想药物的选择性合成生物学方法展望——以铜绿假单胞菌MCCB 117为例研究 翻译改进
Jini Jimmy 1, Jayesh Puthumana 1, Valsamma Joseph 1, I S Bright Singh 2
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DOI: 10.1007/s00284-025-04279-x PMID: 40459729
摘要 中英对照阅读
由铜绿假单胞菌产生的含氮杂环菲嗪化合物吡喃染素已被证明是可持续水产养殖生产系统中治疗弧菌病的潜在首选药物。鉴于生产成本以及自然环境中吡喃染素产量极低的事实，对细菌菌株进行遗传改良以增强吡喃染素的产量是有必要的。先前已经对铜绿假单胞菌中吡喃染素生物合成的关键生物分子进行了深入研究，然而，需要通过基因层面的操作来实验性地提高其在铜绿假单胞菌中的产量。在这篇综述中，我们探讨了铜绿假单胞菌中吡喃染素产生的分子机制，并试图调查微生物合成生物学在吡喃染素生物合成领域的增长前景。鉴于目前基于合成生物学的工具越来越重要，在此情景下，这篇综述旨在为基于合成生物学的吡喃染素生产平台建设提供思路。
© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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