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PURPL directly modulates ULK1 phosphorylation to inhibit autophagic cell death

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Autophagic cell death is characterized by uncontrolled macroautophagy/autophagy overactivation. Yet, the key modulators involved in autophagic cell death remain underexplored. In this study, PURPL (p53 upregulated regulator of p53 levels) is identified to act ... ...