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Review Current microbiology. 2025 May 20;82(7):295. doi: 10.1007/s00284-025-04282-2 Q32.62025

A Critical Review on the Potential of Inactivated Bacteria in Counteracting Human Pathogens

关于灭活细菌对抗人类病原菌潜力的研究进展综述 翻译改进

Aidin Lalezadeh  1, Manouchehr Fadaee  2  3, Samira Saedi  4, Javad Nezhadi  5  6, Mahdi Asghari Ozma  4, Somayeh Ahmadi  4, Mahdi Mobaseri  2, Hossein Samadi Kafil  7

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作者单位

  • 1 Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 3 Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 4 Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • 5 Department of Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. javadnezhadi99@gmail.com.
  • 6 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. javadnezhadi99@gmail.com.
  • 7 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. kafilhs@tbzmed.ac.ir.

    • DOI: 10.1007/s00284-025-04282-2 PMID: 40394322

    摘要 中英对照阅读

    Bacterial infections are a major global public health challenge, especially with increasing antibiotic resistance. Postbiotics, bioactive compounds produced by probiotics, have been proposed as a novel strategy to inhibit the growth of pathogenic bacteria and address antibiotic resistance. Similar to probiotics and certain food ingredients, postbiotics can also modulate beneficial microbial communities and ultimately contribute to host health. Postbiotics ... ...点击完成人机验证后继续浏览

    细菌感染是全球公共卫生的主要挑战，尤其是随着抗生素耐药性的增加。后生物制剂（postbiotics）是由益生菌产生的具有生物活性的化合物，已被提出作为抑制病原菌生长和应对抗生素耐药性的一种新型策略。类似于益生菌和某些食品成分，后生物制剂也可以调节有益微生物群落，并最终有助于宿主健康。从益生菌中衍生出的后生物制剂可能会影响肠道环境的物理和化学条件，并通过增强宿主免疫系统直接干扰病原菌的代谢途径和信号传导。后生物制剂可以抑制生物膜形成、减少抗生素耐药基因表达并提高抗生素治疗的有效性。它们对诸如大肠杆菌和艰难梭菌等耐药细菌有效，同时还能降低由链球菌突变种引起的牙科感染风险。一些后生物制剂，如乳酸和来源于乳杆菌和双歧杆菌属的抗菌肽，有助于免疫系统对抗假单胞菌、金黄色葡萄球菌和幽门螺杆菌等耐药细菌。该综述调查了后生物制剂的作用机制及其在控制病原菌方面的应用，并探讨其作为现有治疗方法补充的角色。

    © 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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    期刊名：Current microbiology

    缩写：CURR MICROBIOL

    ISSN：0343-8651

    e-ISSN：1432-0991

    IF/分区：2.6/Q3

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