Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain
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G-protein-biased agonists have been shown to enhance opioid analgesia by circumventing β-arrestin-2 (βarr2) signaling. We previously reported that SBI-553, a neurotensin receptor 1 (NTSR1)-positive allosteric modulator biased toward βarr2 signaling, attenua... ...
