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5-HT2A receptor inverse agonist attenuates morphine withdrawal syndrome and its aversiveness in rats

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This study explored a potential role for the 5-hydroxytryptamine2A (5-HT2A) serotonin receptor in opiate physical dependence. Rats were rendered opiate-dependent by 7 days of continuous subcutaneous (s.c.) morphine sulfate infusion. Pimavanserin is a selective... ...