Prediction of the Apparent p K a Value of Lipid Nanoparticles by Density Functional Theory
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One of the most important parameters for the development of novel ionizable lipids (ILs) for use in lipid nanoparticle (LNP) drug carriers is their pK a value. Ideally, the LNP should be deprotonated outside the cell to prevent cytotoxicity and protonated insi... ...
