Pharmacologic Targeting of PDIA1 Inhibits NLRP3 Inflammasome Assembly and Activation
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The NLRP3 inflammasome is a cytosolic protein complex that regulates innate immune signaling in response to diverse pathogenic insults through the proteolytic processing and secretion of pro-inflammatory cytokines such as IL-1β. Hyperactivation of NLRP3 infla... ...
