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A large, general and modular DARPin-apoferritin scaffold enables the visualization of small proteins by cryo-EM

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Single-particle cryo-electron microscopy (cryo-EM) has emerged as an indispensable technique in structural biology that is pivotal for deciphering protein architectures. However, the medium-sized proteins (30-40 kDa) that are prevalent in both eukaryotic and p... ...