Decagram-Scale Synthesis of the Novel Bacterial Topoisomerase Inhibitor OSUAB-0284
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Medicinal chemistry efforts identified OSUAB-0284 (2) as a preclinical candidate to treat staphylococcal infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA). Herein, we describe a fit-for-purpose route that enabled the pro... ...
