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Clinical research in cardiology : official journal of the German Cardiac Society. 2025 Apr 22. doi: 10.1007/s00392-025-02650-3 Q13.72025

Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany)

德国VERGE（VA ECMO登记）研究的临床应用及预后影响因素：VA ECMO支持患者的临床转归分析 翻译改进

Tobias Wengenmayer  1, Dawid L Staudacher  2, Alois Philipp  3, Eike Tigges  4  5, Angela Dettling  6, Hendrik Busse  7, Marc Kriege  8, Jan-Sören Padberg  9, Ingo Voigt  10, Clemens Scherer  11, Tobias Graf  12, Dominik Scharpf  13, Peter Noack  14, Simone Britsch  15  16  17, Guido Michels  18; VERGE Study Group

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作者单位

  • 1 Interdisciplinary Medical Intensive Care (IMIT), Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • 2 Interdisciplinary Medical Intensive Care (IMIT), Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany. dawid.staudacher@uniklinik-freiburg.de.
  • 3 Department of Cardiothoracic Surgery, University Medical Center Regensburg, Regensburg, Germany.
  • 4 Asklepios Clinic St. Georg, Cardiology and Critical Care, Hamburg, Germany.
  • 5 DZHK-Deutsches Zentrum Für Herz-Kreislauf-Forschung, Hamburg, Germany.
  • 6 University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • 7 Heart and Vascular Center Bad Bevensen, Bad Bevensen, Germany.
  • 8 Department of Anesthesiology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
  • 9 Department for Cardiology I: Coronary and Periphereal Vascular Disease, Heart Failure, University Hospital Münster, Münster, Germany.
  • 10 Department of Acute and Emergency Medicine, Elisabeth-Hospital Essen, Essen, Germany.
  • 11 Department of Medicine I, LMU University Hospital, LMU Munich, Munich, Germany.
  • 12 University Heart Center Lübeck, Lübeck, Germany.
  • 13 SLK-Kliniken Heilbronn GmbH, Klinikum Am Gesundbrunnen, Medical Department I, Heilbronn, Germany.
  • 14 Department of Cardiology, Intensive Care Medicine, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.
  • 15 Centre for Acute Cardiovascular Medicine Mannheim (DZKAM), Department of Cardiology, Angiology, Haemostaseology and Medical Intensive Care, University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • 16 German Centre for Cardiovascular Research (DZHK), Mannheim, Germany.
  • 17 European Centre for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • 18 Department of Emergency Medicine, Hospital of the Barmherzige Brüder, Trier, Germany.

    • DOI: 10.1007/s00392-025-02650-3 PMID: 40261425

    摘要 中英对照阅读

    The VA ECMO Registry of Germany (VERGE, http://va-ecmo-register.de/ ) is a prospective, multicenter, investigator-driven registry of Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO) all-comers, free from industrial support. VERGE is Germany's first multicenter registry to systematically gather and analyze data from various centers on the clinical use of VA ECMO. This first report compromises data from 581 VA ECMO patients from 2022. Median age was 60 years, hospital survival was 42% and 25% were female. The leading indication for VA ECMO was extracorporeal cardiopulmonary resuscitation (ECPR) followed by VA ECMO in shock (48.9 and 34.9%, respectively). Hospital survival of ECPR was significantly worse compared to shock (28 and 55%, respectively, p < 0.001). Age, pH, and lactate before cannulation all significantly correlated independently with hospital survival (p < 0.001). In VERGE, no patients with pH below 6.7 or lactate above 25 mmol/l survived.

    Keywords: Extracorporeal cardiopulmonary resuscitation (ECPR); Extracorporeal membrane oxygenation (ECMO); Outcome; Shock; Survival.

    Keywords：clinical use; predictors of outcome; verge registry; germany

    德国静脉动脉体外膜氧合（VA ECMO）登记册（VERGE，http://va-ecmo-register.de/ ）是一个前瞻性、多中心的由研究人员驱动的VA ECMO患者登记系统，不接受工业支持。VERGE是德国首个系统地收集和分析来自多个中心关于临床使用VA ECMO数据的多中心登记系统。本报告涵盖了2022年581名VA ECMO患者的资料。中位年龄为60岁，住院生存率为42%，女性占25%。VA ECMO的主要适应症是体外心肺复苏（ECPR），其次是休克中的VA ECMO（分别为48.9%和34.9%）。与休克患者相比，进行ECPR患者的住院生存率明显更差（分别为28% 和55%，p

    关键词：体外心肺复苏（ECPR）、体外膜氧合（ECMO）、结局、休克、生存。

    关键词：静脉动脉体外膜氧合; 临床应用; 预测结局; 德国VENGE Registry

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    期刊名：Clinical research in cardiology

    缩写：CLIN RES CARDIOL

    ISSN：1861-0684

    e-ISSN：1861-0692

    IF/分区：3.7/Q1

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    Clinical use and predictors of outcome in venoarterial extracorporeal membrane (VA ECMO): insights from VERGE (VA ECMO Registry of Germany)