A conserved opal termination codon optimizes a temperature-dependent trade-off between protein production and processing in alphaviruses
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Most mosquito-transmitted alphaviruses encode a premature opal termination codon upstream of their viral polymerase. We show that the Sindbis virus (SINV) opal codon outperforms other stop codons in primate cells at 37°C due to optimal translational readthrou... ...
