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Current microbiology. 2025 Apr 17;82(6):246. doi: 10.1007/s00284-025-04139-8 Q32.62025

Safety and Probiotics Evaluation of Bifidobacterial Genomes Isolated from Probiotic Products

益生菌产品中分离的双歧杆菌基因组的安全性和 probiotic 评价 翻译改进

Jue Li  1  2  3, Yinhuan Wang  1  2  3, Xingyu Xu  4, Xiaoling Zheng  1  2  3, Zhengnan Wang  1  2  3, Xiaofeng Chen  4, Lei Wang  4, Lingfeng Mao  4, Wangqin Ge  4, Huijun Liu  5, Wenwen Gao  5, Tingzhang Wang  5, Zhijian Wang  6  7  8

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作者单位

  • 1 Zhejiang Institute for Food and Drug Control, Hangzhou, 310022, Zhejiang, China.
  • 2 NMPA Key Laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Hangzhou, 310022, Zhejiang, China.
  • 3 Zhejiang Key Laboratory of Biopharmaceutical Contact Materials, Hangzhou, 310022, Zhejiang, China.
  • 4 Hangzhou Baiyi Technology Co., Ltd., Hangzhou, 310020, Zhejiang, China.
  • 5 Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province, Hangzhou, 310012, Zhejiang, China.
  • 6 Zhejiang Institute for Food and Drug Control, Hangzhou, 310022, Zhejiang, China. wangzhijian822@163.com.
  • 7 NMPA Key Laboratory for Testing and Risk Warning of Pharmaceutical Microbiology, Hangzhou, 310022, Zhejiang, China. wangzhijian822@163.com.
  • 8 Zhejiang Key Laboratory of Biopharmaceutical Contact Materials, Hangzhou, 310022, Zhejiang, China. wangzhijian822@163.com.
  • DOI: 10.1007/s00284-025-04139-8 PMID: 40244303

    摘要 中英对照阅读

    Bifidobacterium is a common bacterium colonizing human intestines which is frequently used to produce probiotic-related products. Since the rapid development of probiotic products field over recent years, improving probiotic-related testing methods, as well as conducting systematic safety evaluations is urgently needed. Advances in sequencing technology enable clinicians to access the complete genome of bacteria more effectively via whole genome sequencing... ...点击完成人机验证后继续浏览

    双歧杆菌是一种常见的定植于人类肠道的细菌,常被用于生产益生菌相关产品。由于近年来益生菌产品的快速发展,改善与益生菌相关的检测方法以及进行系统的安全性评估变得非常紧迫。测序技术的进步使临床医生能够通过全基因组测序更有效地获取细菌的完整基因组,从而为益生菌的安全性评价提供了解决方案。在我们目前的研究中,从益生菌产品中分离出七种双歧杆菌样品,并使用基因组分析来改善对双歧杆菌物种和亚种水平上的鉴定。值得注意的是,获得的高质量完整基因组被用于预测七种双歧杆菌菌株中的遗传编码的药物抗性和毒力属性,进一步提高了对益生菌安全性的评价。所有菌株中均呈现了赋予有益功能特性的基因以及与肠道定植和生存相关的基因。此外,结合系统发育树进行全基因组测序分析可以帮助识别亚种,并有助于分析样本之间的同源性差异及已报道的菌株间的不同点。我们的研究评估了主流方法在鉴定益生菌相关产品细菌准确性方面的有效性,并揭露了标签上的欺骗事实。本研究的结果可以为益生菌行业中的亚种水平细菌鉴定提供实验依据,也有助于建立一个标准的安全评价系统。

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    期刊名:Current microbiology

    缩写:CURR MICROBIOL

    ISSN:0343-8651

    e-ISSN:1432-0991

    IF/分区:2.6/Q3

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