Background: Carillon annuloplasty reduces functional mitral regurgitation (FMR) and induces left ventricular (LV) reverse remodeling.

Aims: This analysis determined whether the change in MR parameters correlated with the extent of LV reverse remodeling after Carillon annuloplasty.

Material and methods: This retrospective pooled analysis included prospectively collected data of 113 consecutive patients undergoing successful Carillon annuloplasty with complete 1-year echocardiographic follow-up. Patients had grade 2+ to 4+ FMR, LV end-diastolic diameter >5.5 cm, and LV ejection fraction <50%.

Results: At 1 year, significant improvements occurred in all MR severity and LV reverse remodeling parameters. Reductions in LV end-diastolic volume and LV end-systolic volume correlated with improvements in regurgitant volume (RV) (r = 0.27 and r = 0.34) and effective regurgitant orifice area (EROA) (r = 0.27 and r = 0.34), but not vena contracta (VC) width. Change in LVEF was associated with change in RV (r = -0.30), EROA (r = -0.32), and VC width (r = -0.40). Decreased mitral annular area correlated significantly with reductions in RV (r = 0.28), EROA (r = 0.28), and VC width (r = 0.34). The change in LVEF also significantly correlated with the reduction in LV end-systolic volume (r = -0.69), LV end-diastolic volume (r = -0.24), LV end-systolic diameter (r = -0.31), and LV end-diastolic diameter (r = -0.31). Significant correlation was observed between the change in mitral annulus area and change in RV (r = 0.28), EROA (r = 0.28), and VC (r = 0.34).

Conclusions: Carillon annuloplasty induces LV reverse remodeling in patients with FMR, with reduced LV diameters and improved LVEF. The degree of improvement in echocardiographic MR parameters after the Carillon procedure significantly correlated with the extent of LV reverse remodeling.

Keywords: Carillon; annuloplasty; functional mitral regurgitation; mitral valve.

背景： 卡林顿环修复术可以减少功能性二尖瓣反流（FMR）并诱导左心室逆向重构。

目的： 本分析旨在确定二尖瓣反流参数的变化是否与Carillon环修复术后左心室逆向重构的程度相关。

材料和方法： 这项回顾性汇总分析包括了113名连续接受成功Carillon环修复术且有完整一年超声心动图随访的患者的数据。这些患者的二尖瓣反流等级为2+至4+，左心室舒张末期直径大于5.5厘米，左心室射血分数小于50%。

结果： 在一年后，所有二尖瓣反流严重程度和左心室逆向重构参数均显著改善。左心室舒张末期容积和收缩末期容积的减少与反流体积（RV）（r = 0.27 和 r = 0.34）和有效反流口面积（EROA）（r = 0.27 和 r = 0.34）的改善相关，但不包括收缩静脉宽度。左心室射血分数的变化与RV变化（r = -0.30）、EROA变化（r = -0.32）和收缩静脉宽度变化（r = -0.40）有关。二尖瓣环面积减少显著与RV（r = 0.28）、EROA（r = 0.28）和VC（r = 0.34）的减少相关。左心室射血分数的变化也显著与LV收缩末期容积（r = -0.69）、LV舒张末期容积（r = -0.24）、LV收缩末期内径（r = -0.31）和LV舒张末期内径（r = -0.31）的变化相关。二尖瓣环面积变化与RV变化（r = 0.28）、EROA变化（r = 0.28）和VC变化（r = 0.34）的显著相关性被观察到。

结论： 卡林顿环修复术可以诱导功能性二尖瓣反流患者的心室逆向重构，减少左心室直径并改善左心室射血分数。Carillon手术后超声心动图二尖瓣反流参数的改善程度与左心室逆向重构的程度显著相关。

关键词： 卡林顿；环修复术；功能性二尖瓣反流；二尖瓣。