Current microbiology. 2025 Apr 16;82(6):245. doi: 10.1007/s00284-025-04221-1 Q32.62025
Identification of Chlortetracycline Hydrochloride as a Antibacterial Compound Against Pseudomonas syringae pv. tomato DC3000 Through Natural Products Library Screening
克拉维土霉素通过天然产物库筛选被鉴定为针对丁香假单胞菌番茄致病变种DC3000的抗菌化合物 翻译改进
Lin Jiang 1 2 3, Linghe Huang 1 2, Yajing Wang 1 2, Jing Li 4, Zixian Zeng 1 2, Wenlong Yang 1 2, Sai Jiang 5, Dousheng Wu 6, Zhi Wang 1 2, Shunxiang Li 7 8 9, Yanxia Huang 10 11, Hong Pu 12
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DOI: 10.1007/s00284-025-04221-1 PMID: 40240549
摘要 中英对照阅读
潘氏杆菌（Pseudomonas syringae）可以感染全球超过50种作物，造成显著的经济损失，并且是影响全球农作物的主要细菌病原体之一。目前，针对由Pseudomonas syringae pv. tomato DC3000（Pst DC3000）引起的细菌斑点病没有有效的控制策略。在本研究中，对1680种天然产物进行了高通量筛选以评估其抗菌效果。微生物来源的化合物如硫酸多黏菌素B (1)、盐酸甲烯土霉素 (2)、盐酸四环素 (3)、盐酸氯胍霉素 (4)、盐酸地美环素 (5) 和盐酸多西环素 (6) 对Pseudomonas syringae pv. tomato DC3000（Pst DC3000）表现出强烈的抗菌活性，抑制率超过60%。进一步的研究发现，化合物4的最小抑菌浓度为0.4 μM。经过12小时用12.8 μM的化合物4处理后，细菌杀灭效率达到了98%。此外，化合物4有效地抑制了细菌斑点病的发生。总之，本研究建议微生物来源的天然产物具有作为Pst DC3000有效杀菌剂的巨大潜力，为控制细菌斑点病提供了一种新的方法。
© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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Identification of Chlortetracycline Hydrochloride as a Antibacterial Compound Against Pseudomonas syringae pv. tomato DC3000 Through Natural Products Library Screening