首页 文献索引 SCI期刊 AI助手
登录 注册
首页 正文

BMC gastroenterology. 2025 Apr 15;25(1):260. doi: 10.1186/s12876-025-03845-8 Q42.52024

Development and verification of a radiomics model to forecast Ki67 index and prognosis in advanced gastric tubular adenocarcinoma

用于预测进展期胃管状腺癌ki67指数和预后的影像组学模型的建立及验证 翻译改进

Jiatong Lu  1, Yong Xiao  2, Qiushuang Wang  1, Fangfang Chen  3, Zhi Zeng  3, Junfeng Yan  1, Qiang Li  1, Qiang Tong  4

作者单位 +展开

作者单位

  • 1 Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, Hubei, China.
  • 2 Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • 3 Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
  • 4 Department of Gastrointestinal Surgery I Section, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, Hubei, China. qiangtong@whu.edu.cn.
  • DOI: 10.1186/s12876-025-03845-8 PMID: 40234767

    摘要 中英对照阅读

    Background: The purpose of this research is to evaluate the predictive capabilities of a radiomics model for the Ki67 index and its correlation with prognosis in advanced gastric tubular adenocarcinoma patients.

    Methods: Clinical data from 213 patients were analyzed, categorizing patients into high and low Ki67 index groups. The radiomic features of 192 patients were selected by lasso method and the model was constructed, which was validated using the TCIA dataset. Univariate and multivariate Cox regression analyses were used to further analyze clinical features associated with the prognosis of gastric cancer, radiomic models are also used to assess patient outcomes.

    Results: The radiomics model demonstrated moderate accuracy, with AUC values of 0.634, 0.666, and 0.602 for the training, validation 1, and validation 2 sets, respectively. Additionally, a significant correlation was found between the Ki67 index and radiomics scores, a higher Ki67 index was associated with improved outcomes. Kaplan-Meier analysis showed distinct survival differences between patients with high and low radiomics scores, indicating that higher scores predict better prognosis.

    Conclusions: The radiomics model accurately predicts the Ki67 index and correlates with prognosis in advanced gastric tubular adenocarcinoma, offering valuable insights for clinical decision-making and personalized treatment strategies.

    Keywords: Advanced gastric tubular adenocarcinoma; Ki67; Prognosis; Radiomics.

    Keywords:radiomics model; Ki67 index; advanced gastric cancer; proto-oncogene protein

    背景:本研究的目的是评估预测胃管状腺癌患者Ki67指数的影像组学模型的能力及其与预后的相关性。

                                        <p><strong>方法:</strong>分析了213名患者的临床数据,并将患者分为高Ki67指数组和低Ki67指数组。通过Lasso方法选择了192名患者的影像组学特征,构建了模型并使用TCIA数据集进行了验证。采用单因素和多因素Cox回归分析进一步分析与胃癌预后相关的临床特征,并且也利用影像组学模型来评估患者的结果。</p>
                                        <p><strong>结果:</strong>该影像组学模型表现出中等的准确性,训练集、验证1集和验证2集的AUC值分别为0.634、0.666和0.602。此外,发现Ki67指数与影像组学评分之间存在显著相关性,较高的Ki67指数与更好的结果相关。Kaplan-Meier分析显示高分组患者与低分组患者的生存差异明显,表明较高得分预示着较好的预后。</p>
                                        <p><strong>结论:</strong>该影像组学模型能够准确预测胃管状腺癌的Ki67指数,并且与预后相关,为临床决策和个性化治疗策略提供了有价值的见解。</p>
                              </div>
                                                        <p><strong>关键词:</strong>晚期胃管状腺癌;Ki67;预后;影像组学。</p>        </div>
      <p id="copyright">© 2025. The Author(s).</p>

    
    

    关键词:影像组学模型; 增殖指数Ki67; 晚期胃癌; 原癌基因蛋白

    翻译效果不满意? 用Ai改进或 寻求AI助手帮助 ,对摘要进行重点提炼
    Copyright © BMC gastroenterology. 中文内容为AI机器翻译,仅供参考!

    相关内容

    期刊名:Bmc gastroenterology

    缩写:BMC GASTROENTEROL

    ISSN:1471-230X

    e-ISSN:

    IF/分区:2.5/Q4

    文章目录 更多期刊信息

    全文链接
    引文链接
    复制
    已复制!
    推荐内容
    Development and verification of a radiomics model to forecast Ki67 index and prognosis in advanced gastric tubular adenocarcinoma