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Experimental brain research. 2025 Apr 15;243(5):114. doi: 10.1007/s00221-025-07076-x Q41.72024

Retinal vessel density and cognitive function in healthy older adults

健康老年人的视网膜血管密度与认知功能的关系 翻译改进

Dieter F Kutz  1  2, Justus Obergassel  3, Melanie Mack  4  5, Robert Stojan  4, Boris Schmitz  6  7, Florian Alten  3, Claudia Voelcker-Rehage  4  8  9

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作者单位

  • 1 Department of Neuromotor and Exercise, University of Münster, 48149, Münster, Germany. dieter.kutz@uni-muenster.de.
  • 2 Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, 48149, Münster, Germany. dieter.kutz@uni-muenster.de.
  • 3 Department of Ophthalmology, University of Muenster Medical Center, Muenster, Germany.
  • 4 Department of Neuromotor and Exercise, University of Münster, 48149, Münster, Germany.
  • 5 University of Geneva - Center for the Interdisciplinary Study of Gerontology and Vulnerabilities (CIGEV), Geneva, Switzerland.
  • 6 Faculty of Health, Department of Rehabilitation Sciences, University of Witten, Herdecke, Witten, Germany.
  • 7 DRV Clinic Königsfeld, Center for Medical Rehabilitation, Ennepetal, Germany.
  • 8 Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Münster, 48149, Münster, Germany.
  • 9 JICE, Joint Institute for Individualisation in a Changing Environment, University of Münster and Bielefeld University, Münster, Germany.
  • DOI: 10.1007/s00221-025-07076-x PMID: 40232349

    摘要 中英对照阅读

    The eye is considered a gateway to the brain, as the retina is the only tissue of the central nervous system not protected by bones. This enables non-invasive imaging to provide exceptional insights into the brain. Based on the similarity of brain and retinal structure, it is being investigated whether changes in retinal blood flow could serve as a potential biomarker for cognitive decline. Optical coherence tomography angiography (OCTA) enables an examination of the microcirculation of the retina on the basis of retinal flow registration. Retinal blood flow has been associated with cognitive function and changes have been shown for Alzheimer's patients, whereas data for healthy older subjects are contradictory. The aim of this study was to correlate OCTA parameters with the individual performance in tests assessing the executive functions (EFs) inhibition, updating and shifting in a group of healthy older adults (range: 65-79) using structural equation modeling, with hematocrit serving as a mediator. A model was obtained for vessel density (VD) of the retinal superficial vascular complex and the EF parameters inhibition and updating. The model revealed that only the mediator hematocrit correlated with EF, whereas neither the direct path VD to EF nor the indirect path VD via hematocrit to EF were significantly correlated. Regression analysis with hematocrit yielded significant results for the variable updating. We conclude that higher levels of hematocrit shorten reaction time and the coefficient of variation increases correspondingly, indicating a positive effect of hematocrit on EF.

    Keywords: Ageing; MMSE; MoCA; Optical coherence tomography.

    Keywords:retinal vessel density; cognitive function; older adults

    眼睛被视为通往大脑的门户,因为视网膜是中枢神经系统中唯一没有骨骼保护的组织。这使得非侵入性成像能够提供对大脑的独特见解。鉴于脑部和视网膜结构的相似性,正在研究视网膜血流变化是否可以作为认知功能下降的潜在生物标志物。光学相干断层扫描血管成像(OCTA)基于视网膜血流记录,可以检查视网膜微循环。视网膜血流与认知功能相关,并且对于阿尔茨海默病患者已经显示出变化,但对于健康老年人的数据则存在矛盾。本研究旨在通过结构方程建模,在一组健康的老年人群(年龄范围:65-79岁)中,将OCTA参数与其执行功能测试中的抑制、更新和转换性能相关联,并以红细胞比容作为中介变量。该模型获得了视网膜浅层血管复合体的血管密度(VD)与执行功能参数抑制和更新之间的关联。该模型显示,只有中介变量红细胞比容与执行功能相关,而从直接路径VD到EF以及通过红细胞比容到EF的间接路径均无显著相关性。以红细胞比容进行回归分析对变量更新产生了显著结果。我们得出结论:较高的红细胞比容缩短了反应时间,并且变异系数相应地增加,表明红细胞比容对执行功能有积极影响。

    关键词: 老龄化;MMSE(简易精神状态检查);MoCA(蒙特利尔认知评估量表);光学相干断层扫描。

    © 2025. The Author(s).

    关键词:视网膜血管密度; 认知功能; 老年人群

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    期刊名:Experimental brain research

    缩写:EXP BRAIN RES

    ISSN:0014-4819

    e-ISSN:1432-1106

    IF/分区:1.7/Q4

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